Regina M. Hoffman serves as the executive director of the Patient Safety Authority (PSA). In this capacity, she administers an independent state agency, under an 11-member Board of Directors, charged with taking steps to reduce and eliminate medical errors by identifying problems and recommending solutions to promote patient safety.

Prior to 2016, she served as the director of educational programs with responsibility for the statewide Patient Safety Liaison (PSL) program and education.  Regina not only led the program but also worked directly with facilities to help improve patient safety.  She has conducted multiple educational presentations in Pennsylvania on a variety of patient safety topics, authored articles in the Pennsylvania Patient Safety Advisory and engaged in collaborative work to reduce Surgical Site Infections.  She joined the PSA in 2012 as the PSL for the Central Pennsylvania region. In addition to her work at the PSA, she served as a volunteer faculty member with the former National Patient Safety Foundation (NPSF) and recently served as co-chair of the learning systems subcommittee of the National Steering Committee for patient safety.  Regina was named one of fifty experts leading the field of patient safety by Becker's Hospital Review in 2018 and 2020.​​