She has been with the Patient Safety Authority (PSA) in the capacity of a patient safety advisor since August 2008, working with various Pennsylvania healthcare facilities to reduce medical errors. She has given multiple educational presentations and written journal articles on various patient safety–related topics. She has facilitated collaboration efforts with healthcare facilities in order to improve patient safety with projects focused on blood specimen labeling and preoperative screening. She is a Certified Professional in Patient Safety (CPPS), is certified in Just Culture Training, and is a TeamSTEPPS master trainer.

Previously, Shetterly worked at a Community Health Systems hospital in Berwick, Pennsylvania, assuming various roles and responsibilities including occupational health nurse; director of Performance Improvement; director of Education; director of Infection Control; director of Case Management; risk manager; patient safety officer; director of various inpatient and outpatient units (Oncology, Cardiac Treatment Clinic, Sleep Center, Respiratory Therapy, Pain Clinic); and Women’s Health director, as well as clinical responsibilities as a registered nurse in delivery of patient care.​